The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion
Figure 9
Schematic diagram of eNOS coupling and uncoupling. BH4 binds to the heme oxygenase domain to promote L-arginine substrate binding under eNOS coupling conditions. By contrast, BH2 competes with BH4 at the heme oxygenase domain and promotes molecular oxygen as substrate to produce superoxide and eNOS uncoupling conditions (Adopted from [9]).
