Advances in Pharmacological and Pharmaceutical Sciences / 2010 / Article / Fig 9

Research Article

The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion

Figure 9

Schematic diagram of eNOS coupling and uncoupling. BH4 binds to the heme oxygenase domain to promote L-arginine substrate binding under eNOS coupling conditions. By contrast, BH2 competes with BH4 at the heme oxygenase domain and promotes molecular oxygen as substrate to produce superoxide and eNOS uncoupling conditions (Adopted from [9]).

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.