Chronic Treatment with a Promnesiant GABA-A 𝜶𝟓-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model

Figure 2

Effects of α5IA treatment in Ts65Dn mice trained in the MWM task. TS65Dn mice had impaired performance in the MWM task (comparison with other groups: 𝑃<.025). This deficit was rescued by treatment with α5IA.