Chronic Treatment with a Promnesiant GABA-A 𝜶𝟓-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model

Table 1

Analysis of variance (ANOVA) of microarray data: genotype (Euploids versus Ts65Dn mice) and treatment (Vehicle versus α5IA-treated) were the two main factors. Three-copy genes and IEGs were analyzed separately.

		Analysis of variance (ANOVA) of microarray data
	Total	Genotype-modulated genes	Treatment-modulated genes	Interaction-modulated genes
All genes	13024	848	781	1260
3N genes	56	6	3	5
	Genes	GART, Ifnar-2, Kcnj6, Itsn1, Hlcs, and Sod1	App, Kcnj6, and Sod1	Cbr1, Gabpa, 4931408A02Rik, Hmngn1, and Pcp4
IEGs and BDNF	16	5(***)	3(*)	1
	Genes	BDNF, Cox2, Homer1, GS2, and Arc	Fos, Egr2, and BDNF	BDNF