The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation
Figure 4
Bar graphs (mean and standard error the mean (SEM)) with levels of cytokines (pg/mL) MIP-1β, IL-6, IL-8, and MCP-1 (a) and IL-1β, G-CSF, and GM-CSF (b) in stimulated (LPS 1 ng/mL) whole blood ex vivo from eleven patients (unless otherwise stated) with ulcerative colitis prior to (day 0) and after AndoSan consumption for 12 days. Days 0 and 12 after stimulation are depicted by the first and second bars from the left, respectively. For MIP-1β and IL-8, measurements in nine out of ten patients were available. Corresponding measurements from eleven patients with Crohn’s disease (unless otherwise stated) were significantly reduced for cytokines MIP-1β, MCP-1, IL-8, and IL-1β (c) and G-CSF, IL-17, GM-CSF, and IL-2 (d). For MIP-1β and IL-8, measurements in ten out of eleven patients were available. Despite remeasurement of MIP-1β after dilution of plasma 1/10, high out of range values still occurred. Accordingly, the true concentrations of MIP-1β were even higher. The values between the bar graphs compare with the cytokine levels at day 0 prior to the intake of AndoSan. From [24] where the data was part of scatter plots in Scand J Immunol.
