Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy

Table 1

Effects of 0.5 mg/kg aristolochic acid sodium (AANa) treatment on p-aminohippuric acid in rabbits (𝑛=10).

	Control	AANa treatment	𝑃 value
CL (mL/kg/min)	20.77 ± 3.73	9.10 ± 2.45	.010
𝑘10 (min^−1)	0.091 ± 0.009	0.040 ± 0.009	<.001
𝑘12 (min^−1)	0.053 ± 0.018	0.024 ± 0.005	.104
𝑘21 (min^−1)	0.057 ± 0.008	0.039 ± 0.009	.147
𝛼-𝑡1/2 (min)	5.41 ± 1.10	10.85 ± 2.22	.016
𝛽-𝑡1/2 (min)	25.09 ± 3.25	94.28 ± 28.56	.026
Vc (mL/kg)	228.72 ± 30.38	246.09 ± 36.84	.713
𝑉ss (mL/kg)	404.26 ± 51.28	509.32 ± 165.07	.587
AUC (μg × min/mL)	1291.49 ± 192.96	4376.83 ± 1123.55	.017

∗Data are expressed as the mean ± SE.
CL, clearance; 𝑘, elimination rate constant; 𝑘₁₀, elimination rate constant of the central compartment; 𝑘_12, 𝑘₂₁, the transfer rate constant between the central and peripheral compartments; 𝛼-𝑡_1/2, distribution half-life; 𝛽-𝑡_1/2, elimination half-life; V, volume of the distribution; Vc, volume of the distribution in the central compartment; 𝑉ss, volume of the distribution at steady state; AUC, area under the curve.