Pharmacokinetics of p-Aminohippuric Acid and Inulin
in Rabbits with Aristolochic Acid Nephropathy
Table 1
Effects of 0.5βmg/kg aristolochic acid sodium (AANa) treatment on p-aminohippuric acid in rabbits .
Control
AANa treatment
value
CL (mL/kg/min)
20.77βΒ±β3.73
9.10βΒ±β2.45
.010
()
0.091βΒ±β0.009
0.040βΒ±β0.009
<.001
()
0.053βΒ±β0.018
0.024βΒ±β0.005
.104
()
0.057βΒ±β0.008
0.039βΒ±β0.009
.147
(min)
5.41βΒ±β1.10
10.85βΒ±β2.22
.016
(min)
25.09βΒ±β3.25
94.28βΒ±β28.56
.026
Vc (mL/kg)
228.72βΒ±β30.38
246.09βΒ±β36.84
.713
(mL/kg)
404.26βΒ±β51.28
509.32βΒ±β165.07
.587
AUC (ΞΌgβΓβmin/mL)
1291.49βΒ±β192.96
4376.83βΒ±β1123.55
.017
Data are expressed as the meanβΒ±βSE. CL, clearance; , elimination rate constant; , elimination rate constant of the central compartment; , , the transfer rate constant between the central and peripheral compartments; , distribution half-life; , elimination half-life; V, volume of the distribution; Vc, volume of the distribution in the central compartment; , volume of the distribution at steady state; AUC, area under the curve.