Preparation and In Vitro/In Vivo Evaluation of Vinpocetine Elementary Osmotic Pump System

Table 5

The pharmacokinetic parameters (vinpocetine metabolite apovincaminic acid) in dogs after oral administration of 15 mg vinpocetine osmotic pump controlled release tablets and immediate release-tablets (average ± SD, 𝑛=6).

Parameters	Immediate release tablets	Osmotic pump controlled release tablets
𝑇max (h)	1.67 ± 0.31	4.83 ± 1.02*
𝐶max (ng/mL)	149.28 ± 31.22	52.01 ± 22.39*
AUC (ng/mL·min)	453.20 ± 57.55	377.19 ± 39.89**
T1/2 (h)	4.63 ± 0.64	4.17 ± 0.22**
MRT (h)	6.8 ± 0.86	17.29 ± 1.02*
Ke (h^−1)	0.0851 ± 0.0493	0.1067 ± 0.0981**

* 𝑃<.05, compared to the immediate release tablets (𝑡-test)
** 𝑃>.05, compared to the immediate release tablets (𝑡-test).