A Comparison of the 𝜶2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain

Figure 8

The effects of (a) L-838,417 and (b) TPA023 on quantitative electroencephalogram (EEG) in the telemetered rat. Data are expressed as the total power in the beta frequency of the EEG signal over a four-hour period, as a percentage of vehicle control. Data are means±sed. 𝑛=6. Studies were four-period crossovers, and therefore means and SED’s are adjusted for period and rat effects. ∗∗=𝑃<0.01 compared to vehicle-treated group. Restricted maximum likelihood (REML) analysis, followed by Fisher’s post hoc analysis.

(a)

(b)