Augmentation of Tonic GABAA Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABAA Receptors
SSADH-deficient mice have enhanced tonic GABAA currents in VB TC neurons. (a) and (c) VB TC neurons from SSADH−/− mice display enhanced tonic GABAA currents compared with their WT control littermates. (b) and (d) In TTX, tonic current amplitudes in both SSADH−/− and WT mice are reduced compared to control conditions. CGP55845 reduces the amplitude of the tonic GABAA current observed in SSADH−/− to a similar level found in WT mice. (a–d) reproduced from reference .
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