Augmentation of Tonic GABA_A Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA_A Receptors

Figure 3

SSADH-deficient mice have enhanced tonic GABA_A currents in VB TC neurons. (a) and (c) VB TC neurons from SSADH^−/− mice display enhanced tonic GABA_A currents compared with their WT control littermates. (b) and (d) In TTX, tonic current amplitudes in both SSADH^−/− and WT mice are reduced compared to control conditions. CGP55845 reduces the amplitude of the tonic GABA_A current observed in SSADH^−/− to a similar level found in WT mice. (a–d) reproduced from reference [58].

(a)

(b)

(c)

(d)