Testosterone Increases: Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet

<table>Plasma norepinephrine at the end of the experiment by treatment group (means ± S.E.M.). Open bars: controls, <svg height="10.9125" id="M61" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 35.099998 10.9125" width="35.099998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.9125)">
<g transform="translate(72,-63.27)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">8</tspan>
</text>
</g>
</g>
</svg>, solid black bars: ovarectomy (OVX, <svg height="11.0375" id="M62" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 35.099998 11.0375" width="35.099998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.0375)">
<g transform="translate(72,-63.17)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">6</tspan>
</text>
</g>
</g>
</svg>), gray bars: testosterone treated (T, <svg height="11.0375" id="M63" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 35.099998 11.0375" width="35.099998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.0375)">
<g transform="translate(72,-63.17)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">6</tspan>
</text>
</g>
</g>
</svg>), striped bars: ovarectomy and testosterone treatment (OVX+T, <svg height="10.6" id="M64" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 35.099998 10.6" width="35.099998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.6)">
<g transform="translate(72,-63.52)">
<text transform="matrix(1,0,0,-1,-71.95,63.67)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">7</tspan>
</text>
</g>
</g>
</svg>). One-way ANOVA: <svg height="11.1625" id="M65" style="vertical-align:-0.27588pt" version="1.1" viewbox="0 0 52.6875 11.1625" width="52.6875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.1625)">
<g transform="translate(72,-63.07)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝐻</tspan>
<tspan style="font-size: 12.50px; " x="14.37845" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="26.418839" y="0">9</tspan>
<tspan style="font-size: 12.50px; " x="32.670338" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="35.796089" y="0">6</tspan>
</text>
</g>
</g>
</svg>, <svg height="13.6125" id="M66" style="vertical-align:-2.34499pt" version="1.1" viewbox="0 0 44.3125 13.6125" width="44.3125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.6125)">
<g transform="translate(72,-61.11)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑑</tspan>
<tspan style="font-size: 12.50px; " x="6.6515961" y="0">𝑓</tspan>
<tspan style="font-size: 12.50px; " x="17.054092" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="29.094481" y="0">3</tspan>
</text>
</g>
</g>
</svg>, <svg height="11.25" id="M67" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 48.337502 11.25" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">5</tspan>
</text>
</g>
</g>
</svg>, *<svg height="11.25" id="M68" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 48.337502 11.25" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">5</tspan>
</text>
</g>
</g>
</svg> compared to controls, <sup>++</sup><svg height="11.0625" id="M69" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 48.337502 11.0625" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.0625)">
<g transform="translate(72,-63.15)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">1</tspan>
</text>
</g>
</g>
</svg> compared to testosterone treatment.</table>

Advances in Pharmacological and Pharmaceutical Sciences

fig3

Figure 3

Figure 3: Testosterone Increases: Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet 

Figure 3 | Testosterone Increases: Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet 