An Overview of the CNS-Pharmacodynamic Profiles of Nonselective and Selective GABA Agonists

Figure 1

ΔLogSway (log mm)-ΔSPV (deg/sec) relative effect profile of TPA023 1.5 mg, TPACMP2 0.75 mg, SL65.1498 25 mg, zolpidem 10 mg, and alprazolam 1 mg versus lorazepam 2 mg, respectively. (Blue open square: investigational compound; red closed circle: lorazepam 2 mg; blue dot line: the comparator drug; red dash line: lorazepam 2 mg.)

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