An Overview of the CNS-Pharmacodynamic Profiles of Nonselective and Selective GABA Agonists
Table 3
Use of pharmacodynamic tests in each study.
Study
CHDR99112
CHDR0102
CHDR0105
CHDR0614
CHDR0407
compound
TPA023
TPACMP2
SL65.1498
Alprazolam
Zolpidem
comparator
Lorazepam
Lorazepam
Lorazepam
NA
NA
SEM
Done
Done
Done
Done
Done
Sway
Done
Done
Done
Done
Done
VAS BL
Done
Done
Done
Done
Done
Smooth
ND
ND
Done
Done
Done
Track
ND
ND
ND
Done
Done
ND: not done; NA: not applicable; SEM: saccadic eye movement; Smooth: smooth pursuit; Sway: body sway; VAS BL: VAS Bond and Lader; Track: adaptive tracking.