Preclinical Determinants of Drug Choice under Concurrent Schedules of Drug Self-Administration
Figure 2
Effects of chronic intravenous m-fluoroamphetamine (0.1 mg/kg/hr) administration on choice between cocaine and food in rhesus monkeys (). Abscissae: unit dose of cocaine in milligrams per kilogram per injection. Top ordinate: percent cocaine choice. Middle ordinate: rates of responding in responses per second. Bottom ordinate: number of choices completed. All points represent mean data SEM obtained during the last 3 days of m-fluoroamphetamine treatment. These published data [17] demonstrate that experimental manipulations can selectively decrease cocaine choice without also decreasing rates of responding and the number of choices completed. This profile would be considered ideal for a candidate medication to treat cocaine dependence.
