Table 6: Summary of genes with significantly changed expression (>1.7, <0.5) from 1308 genes in total within gene expression analysis using topic-defined PIQOR skin microarray (Miltenyi Biotech, Cologne, Germany) from NHDF after treatment with polysaccharides of Hp4 (10 μg/mL) compared to an untreated control (=1) for 24 h.

GeneDescription and function according to NCBI gene databaseRelative regulation
(SD %)


LOC387763LOC387763 protein (unknown)2.70/9%
C9ORF16C9ORF16 (unknown)2.37/21%
ACTG2Gamma-2-actin (cell motility)2.01/29%
GJB6Connexin 30 (hyperproliferation)0.48/32%

Cell adhesion and extracellular matrix

L1CAML1 cell adhesion molecule1.93/13%
FGF11Fibroblast growth factor 111.93/13%
PTK7Protein-tyrosine kinase 71.78/19%
FATCadherin-related tumor suppressor1.73/13%
SPARCL1SPARC-like protein 10.48/22%


NNMTNicotinamide N-methyltransferase2.83/17%
CA12_2Carbonic anhydrase XII1.98/11%
SLC20A1Member of solute carrier family 20 (phosphate transporter)1.89/10%
MDH1Cytoplasmic malate dehydrogenase1.84/21%
CFTRcAMP-dependent chloride channel1.80/4%
GLUT1Solute carrier family 2 member 1 (facilitated glucose transporter)1.78/29%
PEG1-MESTMesoderm-specific transcript homolog (mouse)1.71/17%
CYP3A7Cytochrome P450 3A70.47/23%
AFMAfamin (α-albumin)0.33/15%

Receptor signaling

NRP1Neuropilin-1 (CD304 Antigen)1.79/26%
INHBCInhibin βC0.46/19%
CD16IGG FC receptor III-20.43/21%
ZAP70Zeta-chain (TCR) associated protein kinase 70 kDa0.41/24%


EXOSC10Exosome component 102.96/37%
HOXD10Homeobox D102.04/20%
SRRM2Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa1.92/33%
MAZMYC-associated zinc finger protein (purine-binding transcription factor)1.91/17%
ANKRD11Ankyrin repeat domain 111.81/23%
MRPL28Mitochondrial ribosomal protein L281.74/15%
C-FOSG0/G1 switch regulatory protein 70.21/1%

Inflammation, stress, and DNA repair

SOD2Mitochondrial superoxide dismutase 24.78/22%
CMTM7CKLF-like MARVEL transmembrane domain-containing protein 73.86/38%
CXCL1Chemokine (C-X-C motif) ligand 13.33/18%
IKBENuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon3.18/38%
FEN1Flap structure-specific endonuclease 12.34/11%
BGLAPBone gamma-carboxyglutamate (gla) protein2.07/10%
MUTYHA/G-specific adenine DNA glycosylase2.05/20%
BTF2P44Basic transcription factor 2 44 kDa subunit1.99/18%
IKBANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha1.89/5%
SERPIN 1Serine proteinase inhibitor1.83/6%
XBP1X-box binding protein 11.73/12%
HSP90B1Endoplasmin (heat shock protein 90 b1)1.73/21%
POLHPolymerase eta (DNA directed)1.70/20%
IL17AInterleukin 170.45/20%

SD: standard deviations from replicates of three biologic repeats.