Memory-Enhancing Activity of Palmatine in Mice Using Elevated Plus Maze and Morris Water Maze

Table 1

Effect of palmatine and other drugs employed on transfer latency (TL) of mice using elevated plus maze.

Treatments	Dose (kg)^−1	TL (sec) on 10th day	TL (sec) on 11th day
Control (vehicle) for 10 days	10 mL	20.25 ± 2.27	17.13 ± 1.24
Physostigmine for 10 days	0.1 mg	16.38 ± 1.39	8.25 ± 0.88^b
Scopolamine	0.4 mg	19.25 ± 2.16	28.25 ± 1.85^b
Diazepam	1 mg	19.14 ± 2.11	24.57 ± 2.30^a
Palmatine for 10 days	0.1 mg	18.37 ± 1.73	14.13 ± 1.73
Palmatine for 10 days	0.5 mg	15.87 ± 1.72	9.88 ± 0.83^a
Palmatine for 10 days	1 mg	15.75 ± 2.30	8.75 ± 0.75^b
Palmatine for 10 days + scopolamine on 10th day	1 mg + 0.4 mg	15.14 ± 1.98	15.57 ± 1.2^c
Palmatine for 10 days + diazepam on 10th day	1 mg + 1 mg	20.75 ± 2.20	17 ± 1.50^d

𝑛=8 in each group. Values are expressed as Mean ± SEM. Data was analyzed by one-way ANOVA followed by Tukey’s post-hoc test.
𝐹(8, 60) = 1.417; 𝑃=0.02079 (10th day);
𝐹(8, 60) = 21.034; 𝑃<0.0001 (11th day);
^a𝑃<0.05 as compared to control;
^b𝑃<0.01 as compared to control;
^c𝑃<0.001 as compared to scopolamine treated group;
^d𝑃<0.01 as compared to diazepam treated group.