Memory-Enhancing Activity of Palmatine in Mice Using Elevated Plus Maze and Morris Water Maze

Table 3

Effect of palmatine and other drugs employed on time spent in target quadrant of mice using Morris water maze.

Treatments	Dose (kg)^−1	Time spent (sec) in target quadrant (10th day)
Control (vehicle) for 10 days	10 mL	94.38 ± 4.50
Physostigmine for 10 days	0.1 mg	125.88 ± 6.98^a
Scopolamine	0.4 mg	65.50 ± 4.04^a
Diazepam	1 mg	68.13 ± 5.16^a
Palmatine for 10 days	0.1 mg	85.25 ± 4.07
Palmatine for 10 days	0.5 mg	119.63 ± 5.33^a
Palmatine for 10 days	1 mg	124.12 ± 5.26^b
Palmatine for 10 days + scopolamine on 10th day	1 mg + 0.4 mg	109 ± 7.78^c
Palmatine for 10 days + diazepam on 10th day	1 mg + 1 mg	96.5 ± 5.29^d

𝑛=8. Values are expressed as Mean ± SEM. Data was analyzed by one-way ANOVA followed by Tukey’s post-hoc test.
𝐹(8, 63) = 17.197; 𝑃<0.0001;
^a𝑃<0.05 as compared to control;
^b𝑃<0.01 as compared to control;
^c𝑃<0.001 as compared to scopolamine treated group;
^d𝑃<0.05 as compared to diazepam treated group.