Methanolic Root Extract of Rauwolfia serpentina Benth Improves the Glycemic, Antiatherogenic, and Cardioprotective Indices in Alloxan-Induced Diabetic Mice

Table 2

Effect of MREt of R. serpentina on body weights of mice.

Groups	Treatments	Body weight (gm)		Weight change (%)
		Initial weight; at 0 day	Final weight at 14 day
Group I	Distilled water (1 mL/ kg)	28.25 ± 0.85	31.25 ± 0.85	+10.68 ± 1.49
Group II	Alloxan treated (150 mg/kg)	29.25 ± 1.6	26 ± 1.41	−11.08 ± 1.48
Group III	0.05% DMSO (1 mL/kg)	29.5 ± 0.87	26.75 ± 0.63	−9.25 ± 0.62
Group IV	Glibenclamide (5 mg/kg)	29.5 ± 0.5	32 ± 0.71	+8.45 ± 0.89^∗∗∗∗a,b
Group V	MREt (10 mg/kg)	30.75 ± 1.31	29 ± 1.22	−5.69 ± 0.78^∗a
Group VI	MREt (30 mg/kg)	28.50 ± 1.55	26.75 ± 1.65	−6.25 ± 1.05^∗a
Group VII	MREt (60 mg/kg)	27.50 ± 1.5	26.75 ± 1.89	−2.94 ± 2.37^∗∗∗∗a,∗∗b

Values are expressed as mean ± SEM (𝑛=6). *𝑃<0.05, **𝑃<0.01, and ****𝑃<0.0001, when compared with respective group II (a) and III (b). Negative (−)/positive (+) signs represent loss/gain in weights of mice at 14th day.