Advances in Pharmacological and Pharmaceutical Sciences

Research Article

Protective Effects of Methylsulfonylmethane on Hemodynamics and Oxidative Stress in Monocrotaline-Induced Pulmonary Hypertensive Rats

Table 3

Effects of different doses of methylsulfonylmethane (MSM) on the levels of reduced glutathione (GSH) and disulfide-oxidized glutathione (GSSG) and MDA in rats with monocrotaline- (MCT-) induced pulmonary hypertension.


	Control	MCT-induced pulmonary hypertension groups, MSM (mg/kg/day)
	Control	0	100	200	400

GSH (nmol/mL)	543.54 ± 16.22	347.33 ± 41.54*	551.65 ± 93.28	695.95 ± 106.36	774.62 ± 45.62	0.41	<0.01
GSSG (nmol/mL)	50.71 ± 2.17		62.98 ± 9.36	59.05 ± 4.80	51.31 ± 2.41	0.26	0.01

Significant Tukey’s post hoc differences compared with controls are indicated by asterisks (** and *) and is the regression coefficient of the dose-response effect. MCT: monocrotaline; MSM: methylsulfonylmethane; SOD: superoxide dismutase; GSH-Px: glutathione peroxidase; CAT: catalase; GSH: reduced glutathione; GSSG: oxidized glutathione; MDA: malondialdehyde.