Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair
The effects of porcine pancreatic elastase (PPE, 0.3 U/g) on respiratory function in mice and its reversal using the anti-beta1 integrin antibody JB1a (3 mg/kg) in comparison to the anti-beta1 integrin clone B44 (3 mg/kg). (a) The effect of PPE on mean respiratory pressure-volume curves in mice from 35 days (35 d) after instillation and its reversal by JB1a and not B44. (b) Reversal of PPE-induced increase in the quasi-static elastance between 5 and 9 cm H2O by JB1a treatment (). Asterisks denote statistical significance with *, **, and *** in comparison to vehicle.