Antinociceptive and Anti-Inflammatory Activities of Leaf Methanol Extract of Cotyledon orbiculata L. (Crassulaceae)

Table 2

Effect of leaf methanol extract of Cotyledon orbiculata on hot-plate-induced nociception in mice.

Treatment groups	Dose (mg/kg)	Response time (s)
		0 min	15 min	30 min	45 min	60 min
PS	0.25 mL	4.13±0.13	6.63±0.60	4.38±0.78	3.38±0.68	2.75±0.31
C. orbiculata	100	6.63±0.92	10.25±1.46	11.75^∗∗±1.07	7.13±1.27	5.13±0.08
	200	6.63±0.85	7.38±1.08	12.38^+±1.43	6.88±1.57	6.25±1.45
	400	5.25±0.47	19.13^∗±5.01	26.63^++±3.35	22.63^+±3.41	24.5^++±2.55
Morphine	10	3.38±0.64	26.63^++±4.83	36.50^++±6.55	22.88^++±2.93	16.63^++±2.07
DMSO	0.25 mL	5.00±0.76	6.13±0.99	3.88±0.38	4.75±0.86	4.50±0.91

* 𝑃<0.05, **𝑃<0.025, ⁺𝑃<0.02, ⁺⁺𝑃<0.001 versus physiological saline control, ANOVA (𝑛=8). The response time in seconds was expressed as Mean±SEM.
PS: physiological saline.
DMSO: dimethylsulfoxide.