Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats
Figure 2
Effect of coenzyme Q10 (CoQ10) on kidney histopathological picture of doxorubicin- (Dox-) treated and untreated rats. A photomicrograph of a section in rat kidney (H and E ×400) of ((a) and (b)) untreated control and low dose CoQ10 treated (CoQ10L) groups, respectively, with normal structure of renal glomeruli (G) and cortical tubules; (c) high dose CoQ10 treated (CoQ10H) group with normal renal glomeruli (G), but mild degeneration of the epithelial lining of some tubules (arrow); (d) Dox-treated group with dilated Bowman’s space (c), severe degenerative changes observed in the renal tubules with exfoliated cells (T). Some tubules are filled with protein casts (arrows) and some showing cystic dilatation (stars); (e) Dox/CoQ10L group with regeneration of renal tubular epithelial cells and normal morphology of renal cortex and glomeruli (G); (f) Dox/CoQ10H group with marked degeneration of renal tubules with exfoliated epithelial cells and casts (arrows).
