Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats

Table 1

Effect of coenzyme Q10 (CoQ10) on percent of animal mortality, kidney/body weight ratio, blood urea nitrogen (BUN), and creatinine in doxorubicin- (Dox-) induced nephrotoxicity in rats.

Groups	Mortality %	Kd/Wt	BUN; (mg/dL)	Creatinine; (mg/dL)
Control	0	5.9 ± 0.8	8 ± 1	0.95 ± 0.04
CoQ10L	0	5.9 ± 0.6	8 ± 2	0.9 ± 0.1
CoQ10H	0	6.4 ± 0.7	10 ± 1	0.9 ± 0.1
Dox	40^a	7.2 ± 0.6^a	358 ± 97^a	2.6 ± 0.3^a
Dox/CoQ10L	25	6.7 ± 0.8	31 ± 7^b	1.7 ± 0.1^b
Dox/CoQ10H	8	6.8 ± 1.1	98 ± 31^c	1.9 ± 0.2^c

CoQ10L and CoQ10H are rats treated with low and high doses of CoQ10, respectively; Kd/Wt is kidney/body weight * 1000 ratio. Values are representation of 6–11 observations as means ± SEM, except survival which is represented as a percentage. ^aSignificant difference compared to control, ^bsignificant difference compared to Dox group, with no statistically significant difference compared to control, and  ^csignificant difference compared to Dox group, but with also significant difference compared to control group. Results are considered significantly different when 𝑃<0.05.