Curcumin Ameliorates Methotrexate-Induced Nephrotoxicity in Rats
Figure 2
Effect of curcumin on kidney histopathological picture of methotrexate-induced nephrotoxicity in rats (H&E ×200). ((a) and (b)) Sections from control and curcumin-treated groups show normal histological pattern. (c) Methotrexate-treated group shows degeneration of the renal tubules with disruption of the basement membranes in-between the tubules (black arrow). Most of the renal tubules show cystic luminal dilatation and their lining cells are flat (red arrow). Degenerated glomeruli are also observed (star). (d) Kidney tissue from methotrexate plus curcumin treated rats; the histological features in section (c) are greatly improved and nearly back to normal appearance. Still few tubules were dilated (arrow).
