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Advances in Pharmacological Sciences
Volume 2013, Article ID 423750, 9 pages
http://dx.doi.org/10.1155/2013/423750
Review Article

Phytochemistry, Pharmacology and Toxicology of Spilanthes acmella: A Review

1Department of Pharmaceutical Sciences, School of Bioscience and Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh 226025, India
2Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India

Received 18 August 2013; Revised 25 September 2013; Accepted 25 September 2013

Academic Editor: Carlos Tirapelli

Copyright © 2013 Suchita Dubey et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Spilanthes acmella is an important medicinal plant, found in tropical and subtropical countries mainly India and South America. Popularly, it is known as toothache plant which reduces the pain associated with toothaches and can induce saliva secretion. Various extracts and active metabolites from various parts of this plant possess useful pharmacological activities. Literature survey proposed that it has multiple pharmacological actions, which include antifungal, antipyretic, local anaesthetic, bioinsecticide, anticonvulsant, antioxidant, aphrodisiac, analgesic, pancreatic lipase inhibitor, antimicrobial, antinociception, diuretic, vasorelaxant, anti-human immunodeficiency virus, toothache relieve and anti-inflammatory effects. This review is elaborately describing the traditional uses, phytochemistry, pharmacology, and toxicology of this plant. This review would assist researchers to search scientific information in the future.