Antimicrobial, Antioxidant, and Wound Healing Properties of Kigelia africana (Lam.) Beneth. and Strophanthus hispidus DC.
Table 5
Summary of wound closures for selected time points. Values are mean wound area (mm2) ± SEM, for untreated wounds and wounds treated with 1% w/w silver sulphadiazine, 7.5% w/w K. africana extract cream (KAL), and stem bark extract (KASB) of K. africana and leaf extract (SHL), root extract (SHR) of S. hispidus and cream only. rats per group. Data analysed by one-way ANOVA followed by Dunnet’s multiple comparison’s test.
Day
Untreated wounds
Silver sulphadiazine
Cream
KAL
KASB
SHL
SHR
1
519.6 ± 113.0
460.7 ± 100.8*
388.2 ± 119.7*
488.0 ± 108.1
572.6 ± 162.2
538.0 ± 89.4
492.5 ± 62.9
3
400.6 ± 73.0
290.9 ± 77.6**
310.7 ± 111.5
330.5 ± 76.9
319.9 ± 66.2
338.8 ± 60.7
319.7 ± 63.0
5
375.5 ± 117.9
194.9 ± 58.6*
242.3 ± 74.1
264.3 ± 41.5
294.8 ± 58.7
272.1 ± 21.5
269.2 ± 23.0*
7
237.0 ± 45.9
142.4 ± 52.2**
159.32 ± 51.24
138.2 ± 30.9*
165.3 ± 44.9
174.6 ± 15.2
178.0 ± 34.4
9
167.4 ± 42.9
80.5 ± 39.5***
103.4 ± 48.0
72.7 ± 9.9**
100.8 ± 42.8
98.9 ± 13.0
103.5 ± 41.5*
11
112.7 ± 28.6
24.3 ± 18.7***
57.6 ± 29.4
33.6 ± 8.1***
49.4 ± 29.3*
44.6 ± 9.3*
48.6 ± 14.5
13
73.00 ± 26.54
13.5 ± 8.7***
33.6 ± 18.9
13.8 ± 6.5***
24.0 ± 18.8**
22.3 ± 10.0***
24.2 ± 11.9**
15
46.1 ± 20.1
2.4 ± 2.9***
19.9 ± 12.1
5.0 ± 3.3***
8.2 ± 8.1**
6.2 ± 3.4**
8.1 ± 5.0
17
27.7 ± 13.2
0.6 ± 1.4***
9.1 ± 8.3
2.0 ± 2.1**
2.3 ± 2.8*
2.3 ± 2.8**
2.4 ± 2.0**
19
17.7 ± 9.8
0.0**
3.7 ± 4.4
0.0**
0.0**
0.0**
0.0**
21
17.7 ± 9.8
0.0**
0.5 ± 0.8*
0.0**
0.0**
0.0**
0.0**
, **, *** were considered statistically significant compared to the untreated wounds.
