Research Article
Comparative Evaluation of Anti-Inflammatory Activity of Curcuminoids, Turmerones, and Aqueous Extract of Curcuma longa
Table 2
Effect of curcuminoids, turmerones, and COFAE on cotton pellet-induced granuloma in rats.
| | Weight of cotton pellets (mg) (wet) | Inhibition (%) | Weight of cotton pellets (mg) (dry) | Inhibition (%) |
| Vehicle control (10 mL/kg) | 228.6 ± 7.5 | 0 | 51.9 ± 1.1 | 0 | Dexamethasone (0.5 mg/kg) | 101.2 ± 5.7* | 55.7 | 22.7 ± 1.9* | 56.2 | Diclofenac (5 mg/kg) | 111.0 ± 10.4* | 51.4 | 28 ± 1.7* | 46.0 | Curcuminoids (5 mg/kg) | 143.2 ± 7.4* | 37.3 | 32 ± 2.0* | 38.3 | Curcuminoids (25 mg/kg) | 127.5 ± 12.4* | 44.2 | 31.4 ± 0.6* | 39.4 | Curcuminoids (125 mg/kg) | 132.9 ± 9.6* | 41.8 | 34.7 ± 1.2* | 33.1 | Turmerones (0.05 mL/kg) | 140.1 ± 13.5* | 38.7 | 34.5 ± 1.9* | 33.5 | Turmerones (0.1 mL/kg) | 129.0 ± 3.7* | 43.5 | 33.0 ± 1.0* | 36.2 | Turmerones (0.15 mL/kg) | 142.7 ± 8.6* | 37.5 | 33.0 ± 0.7* | 36.2 | COFAE (45 mg/kg) | 127.4 ± 4.7* | 44.2 | 31.7 ± 1.7* | 38.7 | COFAE (90 mg/kg) | 131.0 ± 6.6* | 42.6 | 34.1 ± 0.9* | 34.1 | COFAE (180 mg/kg) | 144.2 ± 4.8* | 36.9 | 35.2 ± 1.3* | 32.1 |
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Values are expressed as mean ± SEM; ; P ≤ 0.05 treated groups versus vehicle control.
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