Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways
Table 9
Effects of duodenally administered aqueous extract of E. speciosa on gastric ulceration and secretion in pylorus-ligated rats treated with indomethacin/carbachol.
Treatment
Dose (mg/kg)
Ulcer index (mean + SEM)
% Inhibition
Mucus production (mg) (mean + SEM)
Volume of gastric juice (mL) (mean + SEM)
Gastric pH (mean + SEM)
Gastric acidity (mEq/L) (mean + SEM)
Control
—
3.80 ± 0.13
—
44.39 ± 4.82
6.91 ± 0.15
2.72 ± 0.11
88.50 ± 5.10
E. speciosa
200
2.68 ± 0.23***
29.47
59.43 ± 4.45
5.02 ± 0.42***
4.02 ± 0.12***
60.50 ± 4.36***
E. speciosa
400
2.40 ± 0.10***
36.84
66.73 ± 5.44*
4.48 ± 0.25***
4.60 ± 0.15***
34.50 ± 3.57***
Ranitidine
100
2.03 ± 0.20***
50.85
49.02 ± 5.31
3.64 ± 0.30***
5.09 ± 0.25***
35.05 ± 3.03***
N = 5 rats per treatment; *P < 0.05, statistically significant relative to control; ***P < 0.001, statistically very highly significant relative to control.
