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Advances in Pharmacological Sciences
Volume 2014 (2014), Article ID 471517, 5 pages
http://dx.doi.org/10.1155/2014/471517
Research Article

Influence of Flunixin on the Disposition Kinetic of Cefepime in Goats

Department of Pharmacology, Faculty of Veterinary Medicine, University of El-Sadat City, Minoufiya 32897, Egypt

Received 20 February 2014; Revised 24 March 2014; Accepted 23 April 2014; Published 5 May 2014

Academic Editor: Antonio Ferrer-Montiel

Copyright © 2014 Mohamed El-Hewaity. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The pharmacokinetic profile of cefepime (10 mg/kg b.w.) was studied following intravenous and intramuscular administration of cefepime alone and coadministered with flunixin (2.2 mg/kg b.w.) in goats. Cefepime concentrations in serum were determined by microbiological assay technique using Escherichia coli (MTCC 443) as test organism. Following intravenous injection of cefepime alone and in combination with flunixin, there are no significant changes in the pharmacokinetic parameters. Following intramuscular injection of cefepime alone and in combination with flunixin, the maximum serum concentration was significantly increased in flunixin coadministered group compared with cefepime alone. However, no significant changes were reported in other pharmacokinetic parameters. The result of in vitro protein binding study indicated that 15.62% of cefepime was bound to goat’s serum protein. The mean bioavailability was 92.66% and 95.27% in cefepime alone and coadministered with flunixin, respectively. The results generated from the present study suggest that cefepime may be coadministered with flunixin without change in dose regimen. Cefepime may be given intramuscularly at 12 h intervals to combat susceptible bacterial infections.