Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats
(a) Effect of PECQ on mean thickness of trabecular bone in the metaphyseal region. Thickness of the trabecular bone significantly decreased in diabetic control (DC) rats when compared to normal control (NC) rats. However, treatment with two different doses of PECQ (DC + CQ1 and DC + CQ2) or with insulin (DC + INS) showed a significant increase in the bone thickness, when compared to diabetic nontreated rats. when compared to NC group; , when compared to DC group. (b) Photomicrographs of the trabecular bone in metaphyseal region. Thinner, disrupted, and reduced number of trabeculae were observed in the diabetic control group (DC) when compared to the normal control group (NC). Further treatment with two doses of PECQ (DC + CQ1, DC + CQ2) and insulin (DC + INS) improved the trabecular bone growth. T: trabecular bone; H and E staining, scale bar: 200 μm.
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