Antihyperglycemic Activity of Houttuynia cordata Thunb. in Streptozotocin-Induced Diabetic Rats

Table 5

Effect of HC on mitochondrial MDA, SOD, CAT, and SDH levels in liver, pancreas, and adipose tissue of diabetic rats.

	Control	Diabetic	GL-10	HC-100	HC-200	HC-400
MDA level (nmol MDA/mg protein)
Liver	6.31±0.322	10.625±0.411^a	7.436±0.331^b	9.95±0.348^a,c	8.253±0.4^a,b,d	7.23±0.335^b,d
Pancreas	3.66±0.29	10.389±0.381^a	5.071±0.327^b	8.965±0.396^a,c	6.082±0.376^a,b,d	4.71±0.373^b,d
Adipose tissue	7.092±0.334	13.19±0.356^a	8.336±0.321^b	11.93±0.383^a,c	10.14±0.287^a,b,c,d	8.218±0.375^b,d,e
SOD activity (units/min/mg protein)
Liver	0.152±0.012	0.04±0.007^a	0.147±0.009^b	0.076±0.021^a	0.114±0.015^b	0.141±0.022^b
Pancreas	0.384±0.024	0.134±0.019^a	0.331±0.04^b	0.17±0.023^a,c	0.276±0.04^b	0.319±0.037^b,d
Adipose tissue	0.512±0.053	0.232±0.018^a	0.482±0.042^b	0.272±0.032^a,c	0.426±0.029^b	0.46±0.057^b,d
CAT (units/min/mg protein)
Liver	21.94±1.415	8.864±1.203^a	18.733±1.326^b	11.611±1.523^a,c	16.631±1.708^b	20.938±2.674^b,d
Pancreas	9.605±0.553	3.828±0.505^a	8.108±1.472^b	4.505±1.026^a	5.738±0.644	7.875±1.041^b
Adipose tissue	13.672±0.896	4.544±0.711^a	10.91±0.857^b	7.172±0.784^a,c	8.325±0.733^a,b	11.841±0.618^b,d,e
SDH activity formazan produced (mM/min/mg/protein)
Liver	1.701±0.066	0.801±0.078^a	1.581±0.064^b	0.829±0.35^a,c	0.883±0.056^a,c	0.930±0.045^a,c
Pancreas	2.071±0.058	0.589±0.046^a	1.882±0.069^b	0.836±0.033^a,c	1.591±0.069^a,b,c,d	1.832±0.067^b,d
Adipose tissue	2.307±0.187	0.73±0.083^a	1.814±0.185^b	0.816±0.056^a,c	1.151±0.103^a,c	1.27±0.064^a,c

All results are expressed as mean ± SEM, 𝑛=6, MDA: malondialdehyde, SOD: succinate dehydrogenase, CAT: catalase. ^a𝑃<0.05 compared to normal control; ^b𝑃<0.05 compared to diabetic control; ^c𝑃<0.05 compared to glibenclamide; ^d𝑃<0.05 compared to HC 100 and ^e𝑃<0.05 compared to HC 200 (one-way ANOVA followed by Tukey’s multiple comparison test).