Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells

Table 1

Cytotoxic activity of coumarins isolated from Prangos ferulacea against human cancer cell lines.

	SKNMC		PC3		H1299
	IC50 (μM)	MAE (%)	IC50 (μM)	MAE (%)	IC50 (μM)	MAE (%)
Osthole	28.81 ± 0.79	69.65 (5.93)	20.1 ± 2.1	70.38 ± 2.6	58.43 ± 2.15	52.18 ± 10.94
Isoimperatorin	182 ± 10.91	63.38 ± (10.94)	119.4 ± 8.65	55.14 ± 1.74	300	13.89 ± 3.01
Oxypeucedanin	300	10	300	10	300	10
Braylin	300	10	300	10	300	10

MAE: maximum antiprolifrative effect.