Clinical Study
Simple and Robust Analysis of Cefuroxime in Human Plasma by LC-MS/MS: Application to a Bioequivalence Study
Table 2
Summary of the stability of cefuroxime in human plasma on different conditions
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| Stability conditions | Concentration (g/mL) | Calculated concentration | Mean ± SD (g/mL) | Accuracy% | RSD% |
| Short-term (6 h, 25°C) | 0.0842 | | 94.97 | 2.75 | 1.68 | | 100.8 | 1.47 | 16.8 | | 97.63 | 0.40 |
| Long-term (145 days, −20°C) | 0.105 | | 98.26 | 4.22 | 1.68 | | 103.0 | 2.25 | 16.8 | | 99.94 | 2.36 |
| Autosampler (20 h, 4°C) | 0.0842 | | 97.76 | 3.89 | 1.68 | | 101.8 | 1.47 | 16.8 | | 98.79 | 1.63 |
| Three freeze-thaw cycles (from 25°C to −20°C) | 0.0842 | | 99.46 | 5.76 | 1.68 | | 102.1 | 1.84 | 16.8 | | 98.65 | 2.15 |
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