Review Article
Melatonin and Ischemic Stroke: Mechanistic Roles and Action
Table 1
Effect of melatonin on ischemic model of rat.
| | Dose | Duration | Effect/result | References |
| | 5 mg/kg b.w, i.p | 30 min before MCAO | ↓ROS, ↓NOX2, and ↓NOX4 expression, ↓TUNEL positive cells | [33] |
| | 5 mg/kg b.w, i.p | 30 min before and 60, 120 min after occlusion | ↓nitrite level, ↓MDA, and ↓Ca2+ |
[34] |
| | 5 mg/kg b.w, i.p | At 90 min of reperfusion | ↑PSD-95, ↑GAP-45, and ↑MMP-9 | [35] |
| | 5 mg/kg b.w, i.p | Prior to MCAO | ↑parvalbumin and ↑hippocalcin ↓Ca2+ | [36] |
| | 5 mg/kg b.w, i.p | Prior to MCAO | ↓phosphorylation of Raf-1, MEK1/2, ERK 1/2, and ↓TUNEL positive cells | [37] |
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