Melatonin and Ischemic Stroke: Mechanistic Roles and Action
Table 2
Effect of melatonin in mice model of ischemic stroke.
Dose
Duration
Effect/result
References
10 mg/kg b.w, i.p
Twice at ischemia reperfusion
↑SIRT1, ↑BCL-2, and ↓Bax. ↓mitochondrial membrane potential, ↑mitochondrial complex I, ↑mitochondrial cytochrome c, and ↓cytoplasmic cytochrome c level