Melatonin and Ischemic Stroke: Mechanistic Roles and Action

Table 2

Effect of melatonin in mice model of ischemic stroke.

Dose	Duration	Effect/result	References
10 mg/kg b.w, i.p	Twice at ischemia reperfusion	↑SIRT1, ↑BCL-2, and ↓Bax. ↓mitochondrial membrane potential, ↑mitochondrial complex I, ↑mitochondrial cytochrome c, and ↓cytoplasmic cytochrome c level	[38]
5 mg/kg b.w, i.v	Upon reperfusion	↑TIMP expression, ↑PAI activity, ↓uPA activity, and ↓MMP-9	[39]
4 mg/kg b.w, oral	After 24 hr ischemia for 29 days through drinking water	↑neuronal survival, ↑rotarod, ↑grip strength, and ↓anxiety and ↓hyperactivity	[40]