Review Article
Melatonin and Ischemic Stroke: Mechanistic Roles and Action
Table 3
Effect of melatonin on OGD model.
| | Dose | Duration | Effect/result | References |
| | 10 and 100 nM | Before OGD for 24 hrs |
↑activation of Akt, ↓phosphorylation of JNK | [41] |
| | 10−5, 10−7, 10−9 | After reperfusion | ↓mitochondrial membrane potential, ↓cytoplasmic cytochrome c and ↓Caspase-3 and ↓DNA damage | [39] |
| | 100 to 250 µM | At time of OGD and oxygen-glucose resupply | ↓mPTP, ↓mitochondrial depolarization, ↓Ca2+ level, ↓Caspase-3 activation, ↓DNA fragmentation, and ↓cytochrome c release | [42] |
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