Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats

Table 2

Effects of lisinopril and fosinopril on the exploratory behaviour of scopolamine-induced amnesic rats in passive avoidance test.

Treatment	Exploration trial (day 1)	Exploration trial (day 2)	Exploration trial (day 3)
Control	19.3 ± 0.95	17.16 ± 1.54	12.67 ± 1.31
Saline control	20.6 ± 1.28	16.00 ± 2.71	14.10 ± 1.92
Scopolamine	37.3 ± 2.55^b	33.5 ± 1.88^b	30.67 ± 1.85^b
Lisinopril (0.225 mg/kg) + scopolamine	39.5 ± 2.91^b	38.22 ± 1.03^b	27.50 ± 2.46^b
Lisinopril (0.45 mg/kg) + scopolamine	34.75 ± 1.88^b	31.00 ± 2.71^b	25.21 ± 1.18
Fosinopril (0.90 mg/kg) + scopolamine	35.75 ± 2.78^b	36.0 ± 2.92^b	25.50 ± 1.08
Fosinopril (1.80 mg/kg) + scopolamine	34.00 ± 3.02^b	28.75 ± 2.45	19.75 ± 1.26

Comparison between control, scopolamine, lisinopril, and fosinopril during the exploration trials in passive avoidance test. Values are mean ± SE, versus scopolamine (), versus scopolamine (), ^aversus control (), and ^bversus control ().