Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats

Table 3

Effects of lisinopril and fosinopril on memory retention behaviour of scopolamine-induced amnesic rats in passive avoidance test.

Treatment	Latency to enter the dark compartment (sec) 24 h after receiving foot shock	Total time spent in light compartment (sec) 24 h after receiving foot shock
Control	51.83 ± 2.71	114.50 ± 3.87
Saline control	49.29 ± 2.21	109.78 ± 2.55
Scopolamine	14.83 ± 1.05^b	57.33 ± 4.23^b
Lisinopril (0.225 mg/kg) + scopolamine	25.68 ± 2.34^b	63.00 ± 5.45^b
Lisinopril (0.45 mg/kg) + scopolamine	27.81 ± 4.78^b	73.67 ± 2.24^a
Fosinopril (0.90 mg/kg) + scopolamine	29.83 ± 4.09	88.66 ± 8.59^b
Fosinopril (1.80 mg/kg) + scopolamine	36.33 ± 2.89	98.17 ± 3.54

Comparisons between control, scopolamine, lisinopril, and fosinopril during the retention trial in passive avoidance test. Values are mean ± SE, versus scopolamine (), versus scopolamine (), ^aversus control (), and ^bversus control ().