Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats

Table 4

Effects of lisinopril and fosinopril during acquisition trials in Morris water maze test.

Treatment	Latency (sec) to locate the hidden platform on day 1	Latency (sec) to locate the hidden platform on day 4	Mean swim speed; (seconds)
Control	44.89 ± 1.42	17.24 ± 0.88	0.166 ± 0.12
Saline control	41.20 ± 1.88	16.18 ± 1.71	0.172 ± 0.22
Scopolamine	53.08 ± 1.56^b	38.42 ± 2.59^b	0.387 ± 0.18^b
Lisinopril (0.225 mg/kg) + scopolamine	50.47 ± 1.45^b	33.64 ± 1.90^b	0.307 ± 0.07^b
Lisinopril (0.45 mg/kg) + scopolamine	46.53 ± 2.08^a	35.93 ± 1.43^b	0.268 ± 0.20^b
Fosinopril (0.90 mg/kg) + scopolamine	47.08 ± 2.58^a	37.42 ± 1.23^b	0.294 ± 0.17^b
Fosinopril (1.80 mg/kg) + scopolamine	49.87 ± 0.89^a	33.10 ± 1.45	0.198 ± 0.18

Comparisons between control, scopolamine, lisinopril, and fosinopril treated groups during acquisition trials on day 1 and day 4, and on the mean swim speed during the Morris water maze test. Values are mean ± SE, versus scopolamine (), versus scopolamine (), versus control (), and versus control ().