High-Dose Estradiol-Replacement Therapy Enhances the Renal Vascular Response to Angiotensin II via an AT₂-Receptor Dependent Mechanism

Figure 2

Effects of vehicle or PD123319, on responses to Ang II infusion. Data are shown as mean ± SEM. The data for RBF are also presented as percentage change from baseline. values were derived from repeated measures ANOVA with factors group, dose (of Ang II), and their interaction. represents for comparison of the response to 300 ng/kg/min in ovariectomized rats treated with estradiol and the vehicle for PD123319 compared with all other groups, derived from Tukey’s post hoc test. per group. MAP, mean arterial pressure; RPP, renal perfusion pressure; RBF, renal blood flow per gram kidney weight; RVR, renal vascular resistance; OV, ovariectomized group.

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