Advances in Pharmacological and Pharmaceutical Sciences / 2016 / Article / Tab 1

Research Article

MDMA Impairs Response to Water Intake in Healthy Volunteers

Table 1

Pharmacokinetic results from Study 1. Values are given as mean ± SD. : area under the curve from 0 to extrapolated to infinity, : plasma clearance, : maximum plasma concentration, : time of maximum plasma concentration, : apparent volume of distribution, : first-order elimination constant, and : half-life.

CompoundMeasureMalesFemales
MDMA alonePrazosin + MDMAMDMA alonePrazosin + MDMA

MDMA (hng/mL)3925 ± 17035156 ± 29713960 ± 18183701 ± 2151
(L/h)33.8 ± 9.330.6 ± 8.936.6 ± 31.036.7 ± 26.8
(ng/mL)241 ± 36247 ± 53222 ± 58220 ± 58
(1/h)0.1 ± 0.020.08 ± 0.020.09 ± 0.020.1 ± 0.02
(h)7.7 ± 2.18.9 ± 2.47.7 ± 1.57.5 ± 2.2
(h)1.9 ± 0.42.4 ± 1.43.1 ± 1.12.7 ± 1.3
(L)353 ± 42368 ± 60361 ± 201356 ± 164

MDA (ng/mL)15.2 ± 3.215 ± 3.816.4 ± 5.114.9 ± 4.8
(hng/mL)323 ± 120337 ± 134359 ± 126325 ± 137

HMMA (ng/mL)226 ± 85196 ± 89183 ± 50171 ± 58
(hng/mL)3404 ± 11203223 ± 10193196 ± 6833004 ± 617
(h)1.8 ± 0.51.9 ± 11.9 ± 0.42.3 ± 0.7

HMA (ng/mL)4.1 ± 14 ± 0.84 ± 0.43.7 ± 0.9
(hng/mL)76.5 ± 34.281 ± 17.980.1 ± 12.187.5 ± 50.3