Methanolic Extract of Ceplukan Leaf (Physalis minima L.) Attenuates Ventricular Fibrosis through Inhibition of TNF-α in Ovariectomized Rats

Table 1

Measurements of heart morphometric.

Parameters	Control (—)	OVX 5	OVX 9	Treatment I	Treatment II	Treatment III	ANOVA
BW (gram)	236.5 ± 14.2	280.8 ± 33.4	264.3 ± 20.0	237.0 ± 19.9	250.8 ± 16.5	252.5 ± 34.6	0.124
LVW (mg)	501 ± 16.2	578.8 ± 54.6^#	547 ± 41.6	502.6 ± 25.1	519.2 ± 40.3	514.5 ± 30.8	0.026
RVW (mg)	127 ± 15.6	136.6 ± 22.0	119.7 ± 16.9	125.4 ± 24.9	121.8 ± 16.9	119.3 ± 8.3	0.706
AW (mg)	82.9 ± 3.4	88.9 ± 10.0	81.5 ± 5.05	88.8 ± 2.9	84.4 ± 5.5	80.3 ± 1.7	0.174
LVW/HW ratio	0.705	0.720	0.731	0.704	0.716	0.720	0.298
HW/BW ratio	3.01 × 10^−3	2.87 × 10^−3	2.85 × 10^−3	3.03 × 10^−3	2.90 × 10^−3	2.85 × 10^−3	0.757

Statistical analysis for body weight using Kruskal-Wallis test as post hoc test. using one-way ANOVA analysis. compared with control (—) using Tukey’s test as post hoc test.
BW: body weight; LVW: left ventricular weight; RVW: right ventricular weight; AW: atrial weight; OVX 5: 5-week ovariectomy; OVX 9: 9-week ovariectomy; Treatments I, II, and III: 9-week ovariectomy with 500, 1500, and 2500 mg/kgBW ceplukan leaf’s methanolic extract, respectively.