Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

Table 1

Effects of naproxen and its metal chelates on acetic acid-induced writhing response in mice.

Group	Dose	Number of writhes (mean ± SEM)	% inhibition of writhing
Control	10 mL/kg	14.2 ± 1.07	—
Standard	25 mg/kg	6.4 ± 0.68	54.93
Naproxen-copper complex	25 mg/kg	5.8 ± 0.86	59.15
Naproxen-copper complex	50 mg/kg	3.8 ± 0.58	73.24
Naproxen-cobalt complex	25 mg/kg	5.6 ± 0.68	60.56
Naproxen-cobalt complex	50 mg/kg	3.6 ± 0.51	74.65
Naproxen-iron complex	25 mg/kg	7.4 ± 0.40	47.89
Naproxen-iron complex	50 mg/kg	5.6 ± 0.51	60.56
Naproxen-silver complex	25 mg/kg	6.6 ± 0.93	53.52
Naproxen-silver complex	50 mg/kg	4.2 ± 0.73	70.42
Naproxen-zinc complex	25 mg/kg	6.0 ± 0.31	57.75
Naproxen-zinc complex	50 mg/kg	4.6 ± 0.68	67.60

Each value represents the mean ± SEM, . was considered significant compared with control.