Advances in Pharmacological and Pharmaceutical Sciences / 2016 / Article / Tab 1

Research Article

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

Table 1

Effects of naproxen and its metal chelates on acetic acid-induced writhing response in mice.

GroupDoseNumber of writhes (mean ± SEM)% inhibition of writhing

Control10 mL/kg14.2 ± 1.07
Standard25 mg/kg6.4 ± 0.6854.93
Naproxen-copper complex25 mg/kg5.8 ± 0.8659.15
Naproxen-copper complex50 mg/kg3.8 ± 0.5873.24
Naproxen-cobalt complex25 mg/kg5.6 ± 0.6860.56
Naproxen-cobalt complex50 mg/kg3.6 ± 0.5174.65
Naproxen-iron complex25 mg/kg7.4 ± 0.4047.89
Naproxen-iron complex50 mg/kg5.6 ± 0.5160.56
Naproxen-silver complex25 mg/kg6.6 ± 0.9353.52
Naproxen-silver complex50 mg/kg4.2 ± 0.7370.42
Naproxen-zinc complex25 mg/kg6.0 ± 0.3157.75
Naproxen-zinc complex50 mg/kg4.6 ± 0.6867.60

Each value represents the mean ± SEM, . was considered significant compared with control.

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