Advances in Pharmacological and Pharmaceutical Sciences / 2016 / Article / Tab 2

Research Article

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

Table 2

Central antinociceptive activity of naproxen and its metal chelates at different time intervals.

Group Dose (mg/kg)⁢Reaction time (sec)
30 min
(% elongation)
60 min
(% elongation)
90 min
(% elongation)

Control6.38 ± 0.345.86 ± 0.466.12 ± 0.23
Morphine 0218.6 ± 0.59
(191.54)
15.86 ± 0.28
(170.65)
13.06 ± 0.72
(113.40)
Naproxen259.97 ± 0.52
(56.27)
11.06 ± 0.45
(88.74)
10.46 ± 0.70
(70.92)
Naproxen5012.12 ± 0.62
(89.97)
11.94 ± 0.80
(103.75)
13.3 ± 0.42
(117.32)
Naproxen-copper complex2510.8 ± 0.33
(69.28)
10.8 ± 0.44
(84.30)
12.4 ± 0.34
(102.61)
Naproxen-copper complex5014.62 ± 0.42
(129.15)
14.8 ± 0.35
(152.56)
14.52 ± 0.49
(137.25)
Naproxen-cobalt complex2511.02 ± 0.48
(72.73)
11.32 ± 0.53
(93.17)
11.96 ± 0.50
(95.42)
Naproxen-cobalt complex5013.38 ± 0.34
(109.72)
15.3 ± 0.86
(161.09)
14.86 ± 0.44
(142.81)
Naproxen-iron complex259.84 ± 0.79
(54.23)
10.78 ± 0.61
(83.96)
11.04 ± 0.52
(80.39)
Naproxen-iron complex5013.5 ± 0.84
(111.60)
13.64 ± 0.69
(132.76)
12.74 ± 0.87
(108.17)
Naproxen-silver complex2510.84 ± 0.55
(69.91)
11.06 ± 0.61
(88.74)
12.32 ± 0.45
(101.31)
Naproxen-silver complex5013.8 ± 0.58
(116.30)
14.18 ± 0.45
(141.98)
13.6 ± 0.42
(122.22)
Naproxen-zinc complex2512.48 ± 0.29
(95.61)
12.86 ± 0.51
(119.45)
12.18 ± 0.54
(99.02)
Naproxen-zinc complex5015.38 ± 0.45
(141.07)
15.44 ± 0.47
(163.48)
15.12 ± 0.31
(147.06)

Each value represents the mean ± SEM (). was considered significant compared with control.

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