Advances in Pharmacological and Pharmaceutical Sciences / 2016 / Article / Tab 3

Research Article

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

Table 3

Effect of naproxen and its metal complexes on the number of entries and time spent in elevated plus maze in acute study.

GroupDose (mg/kg)Observed parameters
Open arm entriesClosed arm entriesTotal entriesTime spent in open armsTime spent in closed arms

Control2.3 ± 0.212.83 ± 0.405.17 ± 0.476.83 ± 0.47293.17 ± 0.47
Diazepam25.17 ± 0.544.5 ± 0.569.67 ± 1.0217.83 ± 0.94282.17 ± 0.94
Naproxen253.17 ± 0.304.0 ± 0.367.17 ± 0.5411.67 ± 0.80288.33 ± 0.80
N-Cu252.83 ± 0.473.33 ± 0.427.17 ± 0.477.67 ± 0.80292.33 ± 0.80
N-Co253.33 ± 0.333.67 ± 0.337.0 ± 0.5713.5 ± 0.99286.5 ± 1.07
N-Fe251.83 ± 0.304.0 ± 0.365.83 ± 0.164.0 ± 0.63296.0 ± 0.63
N-Ag251.5 ± 0.343.83 ± 0.335.17 ± 0.403.67 ± 0.71296.33 ± 0.71
N-Zn253.17 ± 0.493.5 ± 0.426.67 ± 0.6012.67 ± 1.33287.33 ± 1.33

Each value represents the mean ± SEM, . and were considered significant compared with control.

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