Table of Contents Author Guidelines Submit a Manuscript
Advances in Pharmacological Sciences
Volume 2016, Article ID 9463476, 11 pages
http://dx.doi.org/10.1155/2016/9463476
Research Article

Development of an Experimental Model of Diabetes Co-Existing with Metabolic Syndrome in Rats

1Department of Pharmacology, MGM Medical College, Kamothe, Navi Mumbai 410209, India
2Department of Pathology, MGM Medical College, Kamothe, Navi Mumbai 410209, India

Received 8 September 2015; Revised 8 December 2015; Accepted 14 December 2015

Academic Editor: Thérèse Di Paolo-Chênevert

Copyright © 2016 Rajesh Kumar Suman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. G. M. M. Alberti, R. H. Eckel, S. M. Grundy et al., “Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the study of obesity,” Circulation, vol. 120, no. 16, pp. 1640–1645, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. J. S. Torgerson, J. Hauptman, M. N. Boldrin, and L. Sjöström, “XENical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study. A randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients,” Diabetes Care, vol. 27, no. 1, pp. 155–161, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Guilherme, J. V. Virbasius, V. Puri, and M. P. Czech, “Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes,” Nature Reviews Molecular Cell Biology, vol. 9, no. 5, pp. 367–377, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. K.-H. Yoon, J.-H. Lee, J.-W. Kim et al., “Epidemic obesity and type 2 diabetes in Asia,” The Lancet, vol. 368, no. 9548, pp. 1681–1688, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. G. I. Bell and K. S. Polonsky, “Diabetes mellitus and genetically programmed defects in β-cell function,” Nature, vol. 414, no. 6865, pp. 788–791, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. J. E. Shaw, R. A. Sicree, and P. Z. Zimmet, “Global estimates of the prevalence of diabetes for 2010 and 2030,” Diabetes Research and Clinical Practice, vol. 87, no. 1, pp. 4–14, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Unwin, D. Gan, and D. Whiting, “The IDF Diabetes Atlas: providing evidence, raising awareness and promoting action,” Diabetes Research and Clinical Practice, vol. 87, no. 1, pp. 2–3, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. X.-K. Zheng, L. Zhang, W.-W. Wang, Y.-Y. Wu, Q.-B. Zhang, and W.-S. Feng, “Anti-diabetic activity and potential mechanism of total flavonoids of Selaginella tamariscina (Beauv.) Spring in rats induced by high fat diet and low dose STZ,” Journal of Ethnopharmacology, vol. 137, no. 1, pp. 662–668, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Skovsø, “Modeling type 2 diabetes in rats using high fat diet and streptozotocin,” Journal of Diabetes Investigation, vol. 5, no. 4, pp. 349–358, 2014. View at Publisher · View at Google Scholar
  10. R. H. Unger, G. O. Clark, P. E. Scherer, and L. Orci, “Lipid homeostasis, lipotoxicity and the metabolic syndrome,” Biochimica et Biophysica Acta (BBA)—Molecular and Cell Biology of Lipids, vol. 1801, no. 3, pp. 209–214, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. F. Franconi, G. Seghieri, S. Canu, E. Straface, I. Campesi, and W. Malorni, “Are the available experimental models of type 2 diabetes appropriate for a gender perspective?” Pharmacological Research, vol. 57, no. 1, pp. 6–18, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Sahin, M. Onderci, M. Tuzcu et al., “Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat,” Metabolism: Clinical and Experimental, vol. 56, no. 9, pp. 1233–1240, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Srinivasan, B. Viswanad, L. Asrat, C. L. Kaul, and P. Ramarao, “Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening,” Pharmacological Research, vol. 52, no. 4, pp. 313–320, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Kuate, A. Pascale, N. Kengne, C. P. N. Biapa, B. G. K. Azantsa, and W. A. B. W. Muda, “Tetrapleura tetraptera spice attenuates high-carbohydrate, high-fat diet-induced obese and type 2 diabetic rats with metabolic syndrome features,” Lipids in Health and Disease, vol. 14, article 50, 13 pages, 2015. View at Publisher · View at Google Scholar
  15. E. L. B. Novelli, Y. S. Diniz, C. M. Galhardi et al., “Anthropometrical parameters and markers of obesity in rats,” Laboratory Animals, vol. 41, no. 1, pp. 111–119, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. L. S. Mansor, E. R. Gonzalez, M. A. Cole et al., “Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin,” Cardiovascular Diabetology, vol. 12, article 136, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Wang, T. Campbell, B. Perry, C. Beaurepaire, and L. Qin, “Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats,” Metabolism: Clinical and Experimental, vol. 60, no. 2, pp. 298–305, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Kehkashan and A. S. Waseem, “Protective effect of butea monospora on high fat diet and streptozotocin-induced non-genetic rat model of type 2 diabetes: biochemical & histopathological evidence,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 3, no. 3, pp. 74–81, 2011. View at Google Scholar
  19. N. M. El-Sheikh, “Mangifera indica leaves extract modulates serum leptin. Asymmetric dimethylarginine and endothelin-1 leaves in experimental diabetes mellitus,” Egyptian Journal of Biochemistry & Molecular Biology, vol. 30, no. 2, pp. 229–244, 2012. View at Google Scholar
  20. A. A. Kamal, M. A. Ezzar, and A. N. Mohammad, “Effects of panax quindue of olium on streptozotocin induced diabetic rats: role of C-peptide. Nitric oxide & oxitadive stress,” International Journal of Clinical and Experimental Medicine, vol. 4, no. 2, pp. 136–147, 2011. View at Google Scholar
  21. M. R. Shahraki, M. Harati, and A. R. Shahraki, “Prevention of high fructose-induced metabolic syndrome in male wistar rats by aqueous extract of Tamarindus indica seed,” Acta Medica Iranica, vol. 49, no. 5, pp. 277–283, 2011. View at Google Scholar · View at Scopus
  22. R. P. Munshi, S. G. Joshi, and B. N. Rane, “Development of an experimental diet model in rats to study hyperlipidemia and insulin resistance, markers for coronary heart disease,” Indian Journal of Pharmacology, vol. 46, no. 3, pp. 270–276, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Mamikutty, Z. C. Thent, S. R. Sapri, N. N. Sahruddin, M. R. Mohd Yusof, and F. Haji Suhaimi, “The establishment of metabolic syndrome model by induction of fructose drinking water in male Wistar rats,” BioMed Research International, vol. 2014, Article ID 263897, 8 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Zhang, S. Yang, and J. Du, “Protective effects of berberine on isoproterenol-induced acute myocardial ischemia in rats through regulating hmgb1-tlr4 axis,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 849783, 8 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. N. F. Renna, E. A. Diez, and R. M. Miatello, “Effects of dipeptidyl-peptidase 4 inhibitor about vascular inflammation in a metabolic syndrome model,” PLoS ONE, vol. 9, no. 9, Article ID e106563, 2014. View at Publisher · View at Google Scholar · View at Scopus