The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats

Figure 4

Comparison of the histopathology of biopsy samples from second-degree burns on 8 and 21 days after treatment with basic cream (BC), no treatment or normal saline (N/S), standard silver sulfadiazine treatment (SSD 1%), and Punica granatum 5% (P 5%) and Punica granatum 10% ( 10%) creams treatment. Neovascularization activity and fibroblastic proliferation were better in P 5%, 10%, and SSD 1% cream compared with N/S and BC groups on the 8th day. Also, degree of granulation tissue was better in these groups. The thickness of the granular cell layer and the epidermal thickness degree in the wound of Punica 10% and SSD 1% wound treatment were better than in other groups on the 21st day.