Downregulation of Thromboxane A₂ Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery

Figure 3

Effect of NF-κB inhibitors (a) MG-132 and (b) BMS345541 on U46619-induced contraction and TP receptor (c) mRNA expression. Renal artery segments were organ cultured in presence of vehicle (DMSO) or different concentrations of MG-132 (MG, 0.2, 1, or 5 μM) or BMS345541 (BMS, 1, 5, or 25 μM) for 24 h. Data are shown as means ± SEM. Each data point is derived from 6 experiments. One-way ANOVA with Dunnett’s multiple comparison test was used. versus vehicle (DMSO) and n.s. = not significant. BMS = BMS345541, MG = MG-132.

(a)

(b)

(c)