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Cluster | Symbol | Pathways | Diseases |
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1 | CASP3 | Caspase-3 | Cancer |
CASP9 | Caspase-9 | Aging, cancer, chemdependency |
BAX | BCL2-associated X and apoptosis regulator | Colorectal cancer, somatic, T-cell acute lymphoblastic leukemia |
TP53 | Tumor protein p53 | Breast cancer, colorectal cancer, hepatocellular carcinoma, etc. |
BAD | BCL2-associated agonist of cell death | Cancer, hematological, infection |
GSK3B | Glycogen synthase kinase 3 beta | Cancer |
POU5F1 | POU class 5 homeobox 1 | Chemdependency |
MAPK14 | Mitogen-activated protein kinase 14 | Chemdependency |
CREB1 | cAMP responsive element-binding protein 1 | Histiocytoma |
SOX2 | SRY-box 2 | Optic nerve hypoplasia and abnormalities of the central nervous system |
KLF4 | Kruppel like factor 4 | Cardiovascular and metabolic diseases |
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2 | MTOR | Mechanistic target of rapamycin | Aging, cancer, chemdependency |
PRKACA | Protein kinase cAMP-activated catalytic subunit alpha | Cushing syndrome |
MAPK10 | Mitogen-activated protein kinase 10 | Metabolic diseases |
STAT1 | Signal transducer and activator of transcription 1 | Mycobacterial and viral infections |
ACTB | Actin beta | Baraitser-winter syndrome 1 and dystonia |
BCL2L11 | BCL2 like 11 | Cancer, cardiovascular diseases |
SIRT1 | Sirtuin 1 | Aging, cancer, cardiovascular diseases |
TUBB3 | Tubulin beta 3 class III | Fibrosis, cortical dysplasia, brain malformations |
MYC | v-myc avian myelocytomatosis viral oncogene homolog | Burkitt lymphoma |
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3 | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | Aging |
CASP8 | Caspase-8 | Breast cancer, lung cancer |
AKT1 | AKT serine/threonine kinase 1 | Breast cancer, somatic, colorectal cancer, ovarian cancer, schizophrenia |
BCL2 | BCL2, apoptosis regulator | Leukemia/lymphoma |
CYCS | Cytochrome c, somatic | Thrombocytopenia |
MAPK11 | Mitogen-activated protein kinase 11 | Unknown |
MAPK13 | Mitogen-activated protein kinase 13 | Unknown |
CTNNB1 | Catenin beta 1 | Colorectal cancer, hepatocellular carcinoma, ovarian cancer and mental retardation |
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