Evaluation of Novel 3-Hydroxyflavone Analogues as HDAC Inhibitors against Colorectal Cancer

Table 3

Isoform-specific HDAC enzyme inhibition assay.

Sl. no.	Compound	HDAC8	HDAC1	HDAC6
1	QMJ-2	36.03 ± 4.17	34.11 ± 3.83	165.1 ± 11.1
2	QMJ-5	24.00 ± 2.8	47.7 ± 6.3	163.35 ± 7.05
4	Quercetin	15.4 ± 1.53	26.72 ± 3.77	43.39 ± 2.17
3	SAHA	0.7 ± 0.025	0.026 ± 0.002	0.098 ± 0.012

The IC₅₀ (µM) values are expressed as mean ± SEM of three experiments.